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This protective effect of nicotine is related to stimulation of the selectively damaged nigrostriatal dopamine neurons and protection against neuronal insults in experimental PD models (Quik et al., 2003)

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Although the clinical case reports of PG exposures demonstrate that high-dose oral and intravenous exposure to PG can induce toxicity, the relevance of those studies to potential health effects of PG from e-cigarettes depends on the dose and pharmacokinetics of PG following inhalation exposure through e-cigarettes